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小分子筛选平台

时间:2016年05月12日 访问次数:1734

本平台是针对各种试验需求,于小分子库中对其组合、浓度和添加时间等进行高通筛选和优化的系统。目前,干细胞联盟平台的小分子库所包含的小分子具体如下:

 

浙江大学干细胞与转化医学联盟小分子库汇总

 

Name Pathways/Function
Miltefosine PI3K/Akt/mTOR Signaling
Methyl hesperidin PI3K/Akt/mTOR Signaling
Lithium citrate tribasic tetrahydrate Neuroscience; PI3K/Akt/mTOR Signaling
Ellagic acid Enzyme; Metabolism; Cell Cycle/Checkpoint
Cyanoacetohydrazide PI3K/Akt/mTOR Signaling
Niclosamide JAK/STAT Signaling; Ubiquitination
Urea Enzyme
Salinomycin Stem Cell; Microbiology & Virology
Dequalinium chloride Tyrosine Kinase/Adaptors
Fludarabine DNA Damage/DNA Repair;JAK/STAT Signaling
Nifuroxazide JAK/STAT Signaling
Fasudil Tyrosine Kinase/Adaptors
Crizotinib (PF-02341066) Tyrosine Kinase/Adaptors
Y-27632 2HCl Cell Cycle/Checkpoint
SB 431542 Immunology/Inflammation
AZD1080 PI3K/Akt/mTOR Signaling
BIX02188 MAPK Signaling
Kartogenin Immunology/Inflammation
LY2090314 PI3K/Akt/mTOR Signaling
SB525334 Immunology/Inflammation
Smoothened Agonist (SAG) HCl Stem Cell
LDK378(Ceritinib) Tyrosine Kinase/Adaptors
GW788388 Immunology/Inflammation
Purmorphamine Stem Cell
Ruxolitinib (INCB018424) JAK/STAT Signaling
Momelotinib (CYT387) JAK/STAT Signaling
ZCL 278 Cell Cycle/Checkpoint
Y27632 Cell Cycle/Checkpoint; Ubiquitination
LH-846 Stem Cell
XAV939 Stem Cell
AR-A014418 PI3K/Akt/mTOR Signaling
RKI-1447 Cell Cycle/Checkpoint
LDN212854 Tyrosine Kinase/Adaptors
K 02288 Tyrosine Kinase/Adaptors
6-BIO PI3K/Akt/mTOR Signaling; Cell Cycle/Checkpoint
LDE225 (NVP-LDE225,Erismodegib) Stem Cell
Filgotinib (GLPG0634) JAK/STAT Signaling
6H05 Cell Cycle/Checkpoint
LDN-193189 Tyrosine Kinase/Adaptors
Alectinib (CH5424802) Tyrosine Kinase/Adaptors
DMH1 Tyrosine Kinase/Adaptors
ML347 Tyrosine Kinase/Adaptors
LDN-214117 Tyrosine Kinase/Adaptors
AZD2858 PI3K/Akt/mTOR Signaling
ASP 3026 Tyrosine Kinase/Adaptors
Bikinin PI3K/Akt/mTOR Signaling
AZD3463 Tyrosine Kinase/Adaptors
MAY-262611 Stem Cell
k-ras(g12c) inhibitor 6 Cell Cycle/Checkpoint
WHI-P154 JAK/STAT Signaling
Fedratinib (SAR302503, TG101348) Tyrosine Kinase/Adaptors; JAK/STAT Signaling 
Isx 9 Stem Cell
RKI-1313 Cell Cycle/Checkpoint
Oclacitinib JAK/STAT Signaling
CCG-1423 Cell Cycle/Checkpoint
OAC2 Stem Cell
OAC1 Stem Cell
WHI-P131 JAK/STAT Signaling
LY-364947 Immunology/Inflammation
KY0211 Stem Cell
A77-01 Immunology/Inflammation
FH1(BRD-K4477) Stem Cell
SD-208 Immunology/Inflammation
LY2109761 Immunology/Inflammation
Thiazovivin Cell Cycle/Checkpoint
WP1066 JAK/STAT Signaling
2-NP JAK/STAT Signaling
Quercetin Chromatin/Epigenetic
SC-202671 MAPK Signaling
ICG001 Stem Cell
Wnt-C59 Stem Cell
TAE684 (NVP-TAE684) Tyrosine Kinase/Adaptors
IM-12 PI3K/Akt/mTOR Signaling
GHF-5074 Neuroscience;Proteases/Proteasome 
ITD-1 Immunology/Inflammation
BMS-833923 GPCR/G Protein
CHIR-99021 PI3K/Akt/mTOR Signaling
AS601245 MAPK Signaling
BMS-754807 Tyrosine Kinase/Adaptors; JAK/STAT Signaling
Ro-3306 Cell Cycle/Checkpoint; Immunology/Inflammation; MAPK Signaling
Baricitinib (LY3009104, INCB028050) JAK/STAT Signaling
Pirfenidone Immunology/Inflammation
Tofacitinib (CP-690550) Citrate JAK/STAT Signaling
FH535 Stem Cell; Metabolism
BIX02189 MAPK Signaling
CEP-33779 JAK/STAT Signaling
EHop-016 Cell Cycle/Checkpoint
IC261 Stem Cell
TAS-301 Cell Cycle/Checkpoint
D 4476 Metabolism
SANT-1 Stem Cell
ZM 39923 HCl Tyrosine Kinase/Adaptors; JAK/STAT Signaling 
SB-505124 Immunology/Inflammation
ML141 Cell Cycle/Checkpoint
AT13148 PI3K/Akt/mTOR Signaling
Baricitinib (LY3009104, INCB028050) JAK/STAT Signaling
Cerdulatinib JAK/STAT Signaling; Angiogenesis
AZ5104 Tyrosine Kinase/Adaptors
S3I-201;NSC 74859 JAK/STAT Signaling
Galunisertib (LY2157299) Immunology/Inflammation
Hesperetin Immunology/Inflammation
Vitamin E Cell Cycle/Checkpoint; Vitamin
Vismodegib (GDC-0449) Stem Cell
AG-490 (Tyrphostin B42) Tyrosine Kinase/Adaptors; JAK/STAT Signaling 
CHIR-98014 PI3K/Akt/mTOR Signaling
LGK-974 Stem Cell
MK0752 Neuroscience;Proteases/Proteasome 
GSK429286A Cell Cycle/Checkpoint
Decernotinib(VX-509) JAK/STAT Signaling
Gandotinib (LY2784544) Tyrosine Kinase/Adaptors; JAK/STAT Signaling 
IWR-1-endo Stem Cell
SB1317 Cell Cycle/Checkpoint; JAK/STAT Signaling; Tyrosine Kinase/Adaptors 
Taladegib (LY2940680) Stem Cell
JNK-IN-8 MAPK Signaling
AS 602801 MAPK Signaling
IWP-L6 Stem Cell
IWP-2 Stem Cell
TAK901 Cell Cycle/Checkpoint; JAK/STAT Signaling; Tyrosine Kinase/Adaptors 
Myricetrin Immunology/Inflammation
Monocrotaline Immunology/Inflammation
Cryptotanshinone JAK/STAT Signaling
Methyl Vanillate Stem Cell
Daphnetin Tyrosine Kinase/Adaptors; Cell Cycle/Checkpoint
Curcumol JAK/STAT Signaling
Ginsenoside Rg2 PI3K/Akt/mTOR Signaling
Cardamoni JAK/STAT Signaling
2-Methoxy-1,4-naphthoquinone MAPK Signaling
Asiaticoside Immunology/Inflammation
A-83-01 Immunology/Inflammation
ALK inhibitor 2 Tyrosine Kinase/Adaptors
NSC 42834 JAK/STAT Signaling
Ruxolitinib (INCB-18424) phosphate JAK/STAT Signaling
AP26113 Tyrosine Kinase/Adaptors; Immunology/Inflammation
Fasudil (HA-1077) HCl Cell Cycle/Checkpoint
PF06463922 Immunology/Inflammation
WIKI4 Stem Cell
TG101209 Tyrosine Kinase/Adaptors; JAK/STAT Signaling 
Ruxolitinib JAK/STAT Signaling
Tideglusib PI3K/Akt/mTOR Signaling
AT9283 JAK/STAT Signaling; Angiogenesis
AZD1480 JAK/STAT Signaling
GANT61 Stem Cell
XL019 Tyrosine Kinase/Adaptors; JAK/STAT Signaling 
PF670462 Stem Cell
CHIR98014 PI3K/Akt/mTOR Signaling; Tyrosine Kinase/Adaptors
FLI-06 Neuroscience;Proteases/Proteasome
GLPG0634 analogue JAK/STAT Signaling
SB216763 PI3K/Akt/mTOR Signaling
GSK1838705A Tyrosine Kinase/Adaptors
Pyridone 6 JAK/STAT Signaling
   
5-Azac DNA methylation inhibitor
A-83-01 an inhibitor of the TGFβR-1/ALK5
Ascorbic Acid (Vitamin C)  
Bay K8644 Calcium channel agonists
BIX-01294 an inhibitor of G9a histone methyltransferase
CHIR-99021 a GSK-3α and GSK-3β inhibitor. active Wnt signaling
Ciprofloxacin a fluoroquinolone antibiotic and antibacterial
Cyclosporin A an immunosuppressive agent, binds to the cyclophilin and inhibits calcineurin 
Dorsomorphin a potent, reversible and selective AMPK inhibitor.  Inhibit type I BMP receptor activity.
Forskolin (FSK) cAMP activator. a ubiquitous activator of eukaryotic adenylyl cyclase 
Go 6983 a pan-PKC inhibitor
GSK-126 a potent, highly selective EZH2 methyltransferase inhibitor 
I-BET151(GSK1210151A ) a novel selective BET inhibitor for BRD2, BRD3 and BRD4.
IM-12 a GSK-3β inhibitor
ISX9 activation of Ca2+ influx
IWR-1-endo a Wnt pathway inhibitor
LPA (sigma L7260) An agonist of LPA1 and LPA2 receptor
Oct4-activating compound 1 enhance the efficiency of reprogramming 
PD0325901 selective and non ATP-competitive MEK inhibitor 
PGE2-dm enhancing homing, survival, and proliferation of HSCs
Pluripotin (SC1) A sustainer of mES self-renewal and ERK 1 inhibitor
Rapamycin a specific mTOR inhibitor
RepSox(E-616452; SJN 2511) an inhibitor of the TGFβR-1/ALK5
RG108 an inhibitor of DNA methyltransferase
SB431542 an inhibitor of ALK5
SB590885 a B-Raf inhibitor
Sodium butyrate an inhibitor of Histone Deacetylases (HDACs)
Sodium Lactate  
StemRegenin 1 an aryl hydrocarbon receptor(AHR) inhibitor
SU5402 FGFR/VEGFR/PDGFR inhibitor
SW033291 an inhibitor of 15-PGDH(15-hydroxyprostaglandin dehydrogenase)
Tranylcypromine(2-PCPA) a monoamine oxidase inhibitor,inhibits CYP2A6
Trichostatin A an HDAC inhibitor
TTNPB(Arotinoid Acid)  a potent RAR agonist, and inhibits binding of [3H]tRA
UM171  an enhancer of aryl hydrocarbon receptor(AHR) antagonists
UM729 an enhancer of aryl hydrocarbon receptor(AHR) antagonists
Valproic Acid  an inhibitor of Histone Deacetylases (HDACs)
WH-4-023 an orally active Lck/Src inhibitor
Y-27632 2HCL a ROCK1 inhibitor
PGE2P enhancing homing, survival, and proliferation of HSCs